"Resveratrol"

Resveratrol(3,5,4-trihydroxy-transstibene)is a phytoalexin produced naturally by several plants when under attack by pathogens such as bacteria or fungi.Resveratrol is currently a topic of numerous animal and human studies into its effects.The effects of resveratrol on the lifespan of many model organisms remain controversial,with uncertain effects in fruit flies,nematode worms,[1] and short lived fish.In mouse and rat experiments,anti-cancer,anti-inflammatory,blood-sugar-lowering and other beneficial cardiovascular effects of resveratrol have been reported.Most of these results have yet to be replicated in humans.In the only positive human trial,extremely high doses(3-5g)of resveratrol in a proprietary formulation have been necessary to significantly lower blood sugar.[2] Despite mainstream press alleging resveratrol's anti-aging effects,[3] there is little present basis for the application of these claims to mammals.Resveratrol is found in the skin of red grapes and is a constituent of red wine,but apparently not in sufficient[citation needed] amounts to explain the French Paradox.Resveratrol has also been produced by chemical synthesis(metabolic engineered microorganisms)[5] and is sold as a nutritional supplement derived primarily from Japanese Knotweed...